Klinische Studien

Klinische Studien

In recent years, the use of NMR Spectroscopy has become increasingly widespread in various clinical studies. Progression of therapy can be documented by observing a change in concentration of certain metabolites found in body fluids or cell systems. Moreover, statistical analysis can be performed (see figure below), thereby making it possible to detect the appearance of abnormal metabolic products more rapidly and accurately than by conventional methods.

Spektrum 6

The figure below shows a comparison of spectra taken in a clinical study on the treatment of diabetes mellitus II. The spectra show the decrease of 13C-labelled glucose over time, while lactate intensity increases simultaneously. Solche Tests können verwendet werden, um die Auswirkungen von Arzneimitteln direkt zu beobachten.

Spektrum 6
Zeit-abhängige Änderung in 1H -13C - Glukose-Konzentration in menschlichen Erythrocyten bei Diabetes mellitus II